Pancreatic Cancer and Tumor Microenvironment
by Paul J. Grippo, Hidayatullah G. Munshi
Publisher: Transworld Research Network 2012
Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. The DR is composed of extracellular matrix (ECM) proteins, fibroblasts, stellate cells, endothelial cells, immune cells, and neurons. Accumulating evidence indicates that the epithelial and stromal compartments interact to enhance the aggressive nature of this disease.
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